Gene summary for Gli1

#### Genome Browser Links: [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=GLI1) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=GLI1) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=GLI1) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=GLI1) #### Reference Images: | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| |  |  |  |  | #### Gene expression in the secondary palate: _Gli1_ is expressed in the oral mesenchyme and oral epithelium along the AP axis at E13.5. At E14.5, expression is restricted to the oral mesenchyme of the anterior region of the palate. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** | {width=100} | {width=100} | {width=100} | {width=100} | | **Intraoral** | {width=100} | {width=100} | {width=100} | {width=100} | N: Nasal Pr: Proximal Di: Distal O: Oral  Oral mesenchyme  All mesenchyme (AP axis)  Anterior mesenchyme (AP axis) #### Gene expression in the soft palate: In the E14.5 soft palate, _Gli1_ is predominantly expressed in the cranial neural crest (CNC)-derived cells in the TVP, PLG and LVP regions. _Gli1_ expression is also seen in the myogenic cells, epithelium, pterygoid plate and mesenchyme surrounding the epithelium.  In the E16.5 soft palate, the majority of _Gli1_ expression is present in the CNC-derived mesenchyme cells surrounding the TVP, PLG and LVP myogenic fibers. A smaller amount can be also found in the myogenic cells. _Gli1_ expression is also observed in the epithelium, parts of the pterygoid plate and mesenchyme closely surrounding the epithelium.  In the E18.5 soft palate, _Gli1_ expression remains low, except for a few positive cells detectable at the level of TVP, PLG and LVP mostly in the CNC-derived cells. Scattered _Gli1_ expression is also observed in the part of pterygoid plate, epithelium and mesenchyme closely surrounding the epithelium.   #### Sources: - Han et al. (2009) [Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.](http://www.ncbi.nlm.nih.gov/pubmed/19934017) Development 136(24):4225-33. - Rice et al. (2006) [Expression patterns of Hedgehog signalling pathway members during mouse palate development.](http://www.ncbi.nlm.nih.gov/pubmed/16168717) Gene Expr. Patterns 6(2):206-12. - Janečková et al. (2019) [Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development.](http://https://www.ncbi.nlm.nih.gov/pubmed/31613912) PLOS ONE 14(10):e0223879. #### External Links: - [Gli1 GLI-Kruppel family member GLI1 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/14632) - [Gli1 GLI family zinc finger 1 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/2735) - [Gli1 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=GLI1&search=gli1) - [Gli1 Wikipedia](http://en.wikipedia.org/wiki/Gli1)