Crystal structure of the PI5P4Kbeta N203D-ITP complex

Crystal structure of the PI5P4Kbeta N203D-ITP complex Descriptor: INOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate Authors: Senda, M, Senda, T. Deposit date: 2021-04-13 Release date: 2022-03-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.95 Å) Cite: The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022PI5P4Kβ N203D突变体与肌苷三磷酸（ITP）复合物的晶体结构 描述符：肌苷-5'-二磷酸（INOSINE-5'-DIPHOSPHATE）、磷脂酰肌醇5-磷酸4-激酶2型β（Phosphatidylinositol 5-phosphate 4-kinase type-2 beta）、[[(2R,3S,4R,5R)-3,4-二羟基-5-(6-氧代-1H-嘌呤-9-基)四氢呋喃-2-基]甲氧基氧代磷酰基]膦酸氢酯 作者：Senda M、Senda T 沉积日期：2021-04-13 发布日期：2022-03-30 最后修改日期：2023-11-29 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.95埃（Å） 引用文献：PI5P4Kβ的GTP响应特性源于活性与特异性间失衡的权衡演化，《Structure》，第30卷，2022年