Whole-body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal

Opioid use in the United States and abroad is an endemic part of society with yearly increases in overdose rates and deaths. As rates of overdose incidence increase, the use of the safe and effective reversal agent, naloxone, in the form of a nasal rescue spray is being fielded and used by emergency medical technicians (EMTs) at a greater and greater rate. Despite advances in the deployment of these rescue products, deaths are continuing to increase. There is evidence that repeated dosing of a naloxone nasal spray (such as Narcan) is becoming more common due to the amount and type of opiate being administered. Despite the benefits of naloxone related to opioid reversals, we lack repeated dosing guidelines as a function of opiates and the amount the patient has taken. Goal-directed rescue dosing, where respiratory markers such as oxygen saturation or end-tidal carbon dioxide, are being used as an indication of the patient's recovery. These rescue methods require time, training, and under..., Data was collected via the BioGears physiology engine. Python code used to generate data is included in the zip., , # Whole-body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal

[https://doi.org/10.5061/dryad.3tx95x6pr](https://doi.org/10.5061/dryad.3tx95x6pr)

Experimental and simulated data to investigate respiratory depression associated with fentanyl overdose and naloxone reversal administration.

## Description of the data and file structure

The data, once unzipped is in the following structure:

* Data

* Naloxone PK data
* /reversal

* /RepeatExperiment - Naloxone reversal data (units included in files) with Python notebook to generate figures

* /bolus - Fentanyl bolus data
* /Opiod - Experimental fentanyl data, extracted from cited publications and notebook to generate figures

* /modelData - Experimental and simulated data for CO2 responses and respiratory depression

* /StepInfusionResults - Figures from a single simulated experiment

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