Crystal structure of M-PMV dUTPase with a mixed population of substrate (dUPNPP) and post-inversion product (dUMP) in the active sites

Protein Data Bank Japan2023-09-13 更新2026-03-21 收录

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Crystal structure of M-PMV dUTPase with a mixed population of substrate (dUPNPP) and post-inversion product (dUMP) in the active sites Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... Authors: Barabas, O, Nemeth, V, Vertessy, B.G. Deposit date: 2011-09-08 Release date: 2011-10-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Snapshots of Enzyme-Catalysed Phosphate Ester Hydrolysis Directly Visualize In-line Attack and Inversion to be published

活性位点中同时存在底物（dUPNPP）与反转后产物（dUMP）混合种群的M-PMV脱氧尿苷三磷酸酶（dUTPase）晶体结构描述符：2'-脱氧尿苷5'-α,β-亚氨基三磷酸、2'-脱氧尿苷5'-单磷酸、2-氨基-2-羟甲基丙烷-1,3-二醇等。作者：Barabas, O、Nemeth, V、Vertessy, B.G. 存档日期：2011-09-08 发布日期：2011-10-12 最后修改日期：2023-09-13 实验方法：X射线衍射（分辨率1.75埃）引用文献：《酶催化磷酸酯水解的结构快照：直接可视化直列式亲核进攻与构型反转》（待发表）

创建时间：

2011-09-08