Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2149

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2149 Descriptor: 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide, Activin receptor type I, SULFATE ION Authors: Adamson, R.J, Williams, E.P, Smil, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. Deposit date: 2019-10-18 Release date: 2019-10-30 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. J.Med.Chem., 63, 2020

ACVR1（ALK2）激酶与化合物M4K2149结合的晶体结构。配体与体系描述：2-甲氧基-4-[4-甲基-5-(4-哌嗪-1-基苯基)吡啶-3-基]苯甲酰胺，该靶点为激活素I型受体（Activin receptor type I），体系包含硫酸根离子（SULFATE ION）。作者：Adamson, R.J.、Williams, E.P.、Smil, D.、Burgess-Brown, N.、von Delft, F.、Arrowsmith, C.H.、Edwards, A.M.、Bountra, C.、Bullock, A.N.。沉积日期：2019-10-18；发布日期：2019-10-30；最后修改日期：2024-10-23。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.56 Å。引用文献：《靶向ALK2：开发弥漫内生型桥脑胶质瘤治疗疗法的开放科学路径》，发表于《J.Med.Chem.》，2020年，第63卷。