mTopic - Supplementary RDS data

Uploaded files are raw (*_raw.rds) and filtered (*_filtered.rds) RDS objects used for R tutorials of mTopic. Single-cell data processed here are publicly available from the Gene Expression Omnibus (GEO) and 10x Genomics: P22 mouse brain dataset (P22_Mouse_Brain_ATAC_RNA) [1] – GSE218593 (GSM6753043) for RNA– GSE205055 (GSM6758285) for ATAC Human tonsil dataset (Human_Tonsil_RNA_Protein)Available from 10x Genomics here. Human PBMC dataset (Human_PBMC_ATAC_RNA_Protein) [2]GSE166188– GSM5065524 for ATAC– GSM5065525 for RNA– GSM5065526 for protein References[1] Zhang D, Deng Y, Kukanja P, Agirre E et al. Spatial epigenome-transcriptome co-profiling of mammalian tissues. Nature 2023 Apr;616(7955):113-122. PMID: 36922587[2] Mimitou EP, Lareau CA, Chen KY, Zorzetto-Fernandes AL et al. Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells. Nat Biotechnol 2021 Oct;39(10):1246-1258. PMID: 34083792