Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, MONOPOLAR SPINDLE KINASE 1, ... Authors: Gurden, M.D, Westwood, I.M, Faisal, A, Naud, S, Cheung, K.M, McAndrew, C, Wood, A, Schmitt, J, Boxall, K, Mak, G, Workman, P, Burke, R, Hoelder, S, Blagg, J, van Montfort, R, Linardopoulos, S. Deposit date: 2015-09-14 Release date: 2015-09-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Naturally Occurring Mutations in the Mps1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res., 75, 2015

MPS1基因天然存在的突变可赋予细胞对激酶抑制剂的耐药易感性。描述符：1,2-乙二醇（1,2-ETHANEDIOL）、二甲基亚砜（Dimethyl Sulfoxide）、单极纺锤体激酶1（Monopolar Spindle Kinase 1）等。作者：Gurden, M.D、Westwood, I.M、Faisal, A、Naud, S、Cheung, K.M、McAndrew, C、Wood, A、Schmitt, J、Boxall, K、Mak, G、Workman, P、Burke, R、Hoelder, S、Blagg, J、van Montfort, R、Linardopoulos, S。提交日期：2015-09-14；发布日期：2015-09-23；最后更新：2024-01-10。检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.45埃（Å）。引用文献：《MPS1基因天然存在的突变可赋予细胞对激酶抑制剂的耐药易感性》，《癌症研究》（Cancer Res.），第75卷，2015年。