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UTX loss affect lymphoma initiation and progression
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2018-03-13
相关数据集
Transcriptome analysis of bladder urothelium from control and Utx-deficient mice with wild-type or heterozygous for p53.. Mus musculus
UTX (Ubiquitously transcribed tetratricopeptide repeat, X chromosome, also known as KDM6A) mutations are frequently found in urologic tumors including BC, strongly suggesting that UTX plays fundamenta
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Exon 1 Disruption Alters Tissue-Specific Expression of Mouse p53 and Results in Selective Development of B Cell Lymphomas
p53 is a tumor suppressor gene mutated in >50% of human cancers, while p53 deficiency in mice results in cancers and accelerated mortality. Thymic T cell lymphoma is the most common malignancy in p53-
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Effect of deletion of UTX expression in NY8.3 progenitor CD8+ T cells
Type 1 diabetes (T1D) is a chronic autoimmune disease resulting from the destruction of insulin-producing beta cells. This persistence is due to the continual replenishment of short-live effector CD8+
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CD137 (4-1BB) ligand mediates CD4 T-cell immuno-surveillance of pre- lymphoma B cells in a lymphoma-prone mouse model. CD137 (4-1BB) ligand mediates CD4 T-cell immuno-surveillance of pre- lymphoma B cells in a lymphoma-prone mouse model
Aberrant expression of the proto-oncogene BCL6 is a driver of tumorigenesis in diffuse large B cell lymphoma (DLBCL). Mice overexpressing BCL6 from the B cell-specific immunoglobulin heavy chain μ int
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Table_1_Mouse Models of Germinal Center Derived B-Cell Lymphomas.docx
Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose
NIAID Data Ecosystem30
