Molecular mechanism of serine threonine phosphatase Stp1 regulating virulence in Staphylococcus aureus

SerineThreonine Phosphatase (STP) is a bacterial metal-dependent protein phosphatase (PPM),Stp1 It can regulate the secretion and expression of various virulence factors, and plays a key role in cell wall biosynthesis and drug resistance of Staphylococcus aureus. It is an important protein molecule that plays a role in the pathogenicity of STaphylococcus aureus. In order to verify the regulatory effect of Stp1 on bacterial virulence genes, USA300 was detected by RNA-seq The analysis results of differentially expressed genes in wild type and stp1 knockout strains showed that there were 104 up-regulated genes in wild type and stp1 knockout strains. KEGG and GO analysis of 93 down-regulated genes showed that these genes were mainly involved in various metabolic processes, drug resistance and two-component systems