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资源简介：
NGS Raw sequencing data for different base editors analyzed.
应用场景：
创建时间：
2025-03-12
相关数据集
Raw sequence reads
Cas9-orthologue-mediated cytosine and adenine base editors recognizing NNAAAA PAM sequences
NIAID Data Ecosystem90
Adenine base editing of the DUX4 polyadenylation signal for targeted genetic therapy in Facioscapulohumeral muscular dystrophy
Facioscapulohumeral muscular dystrophy (FSHD) is caused by chromatin relaxation of the D4Z4 repeat resulting in misexpression of the D4Z4-encoded DUX4 gene in skeletal muscle. One of the key genetic r
NIAID Data Ecosystem50
Programmable RNA base editing with a single engineered protein
Programmable base editing of RNA enables rewriting the genetic codes on specific sites. Current tools for specific RNA editing dependent on the assembly or recruitment of the guide RNA into an RNA/pro
NIAID Data Ecosystem40
Additional file 3: of Clinical and genetic characteristics of Chinese patients with familial or sporadic pediatric cataract
Table S3. Target NGS analysis. (XLS 28Â kb)
NIAID Data Ecosystem80
Develop an ecDHFR-regulated RESCUE system, ecRESCUE, with reduced RNA off-targeting activity
Currently, RESCUE RNA base editor proposes great potential for treating genetic diseases at transcription level. The relatively high off-target events are one of the main constrains for precisely RNA
NIAID Data Ecosystem50
