Enzyme-treated Polygonatum odoratum alleviates cyclophosphamide-induced immune injury by modulating the liver-gut axis and the JAK/STAT3 signaling pathway

ETP treatment significantly alleviated CTX-induced dysbiosis of the gut microbiota and improved its diversity. Furthermore, it effectively suppressed the activation of the JAK-STAT3 signaling pathway. These superior effects, compared to the conventional extract, are linked to ETP's unique chemical profile, which is characterized by a higher abundance of bioactive terpenoids and flavonoids.ETP 干预可显著缓解 CTX 诱导的肠道菌群失调（dysbiosis of the gut microbiota），并提升菌群多样性。此外，其可有效抑制 JAK-STAT3 信号通路（JAK-STAT3 signaling pathway）的激活。相较于传统提取物，ETP 的上述优异功效与其独特的化学特征紧密相关，该特征表现为其富含生物活性萜类化合物（terpenoids）与黄酮类化合物（flavonoids）。