RNA-seq analyses of liver samples in mice fed normal diet or subject to 60% high fat diet for 23 weeks

To systemically identify the long non-coding RNAs(lncRNAs) expression profile in the liver, specifically those involved in lipid metabolism, we generated a hyperlipemia model in mice. The hyperlipemia protocol was as follows:mice post natal 4 weeks fed normal diet or subjet to 60% high fat diet for 23 weeks, the mice were immediately sacrificed for liver and plasma collection. Overall design: In this study presented here,we separate mouse livers fed normal diet or subject to 60% high fat diet for 23 weeks and identified the genome-wide expression level of lncRNAs.