The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [RNA-Seq rescue_SS]
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This work shows that the exosome modulates the levels of LINE-1 retrotransposons, miRNAs, lncRNAs and specific mRNAs that encode developmental regulators or affect their expression. The exosome restrains differentiation in part by degrading transcripts encoding FOXH1, a transcription factor crucial for mesendoderm formation.
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NIH创建时间：
2022-02-20
