Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP510306
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Our study identified a druggable component of the tumor stroma that fulfills the metabolic requirement of tumor cells to acquire a more aggressive phenotype. Overall design: The p16INK4a+ and p16INK4a- lung fibroblasts and tdTomato+ LUAD cells of KPTI mice were isolated by Fluorescence-activated cell sorting (FACS) according to the presence of eGFP signal and analyzed using scRNAseq. tdTomato+ tumor cells were isolated by FACS after digestion of tumor organoids. KPTI mouse lung sections and human LUAD sections were analyzed by Xenium for spatial transcriptomics data.
创建时间：
2024-08-28
