Identifying and Understanding Drivers of Chemoresistance in Small Cell Lung Cancer
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs004087.v1.p1
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Using a patient derived model of small cell lung cancer, the KEAP1 gene was deleted using lentiviral expression of a vector expressing CAS9 and single guide RNA (sgRNA) targeting KEAP1. A control vector expressing model was also generated. RNA-Seq analysis was performed to compare gene expression in tumors growing in vivo, comparing KEAP1 deleted to control tumors under saline-treated and cisplatin/etoposide-treated conditions. ]]>
创建时间：
2025-06-04
