hnRNPI Gut Microbiota Dysbiosis_Supplemental Figures and Tables

This study identifies <i>P. bifermentans</i> and <i>Dubosiella</i> sp. as potential gut microbiota signatures in <i>hnRNPI</i> KO mice. KO mice were more susceptible to exacerbated colitis during the DSS challenge. Additionally, bacterial metabolites produced by <i>P. bifermentans</i> and <i>D. newyorkensis</i> may influence colon health in <i>hnRNPI</i> KO mice. Predicted pathway analysis from 16S rRNA gene sequencing revealed significant differences in pathways related to human diseases, including cancer. Finally, this study demonstrates that genetic aberrations, specifically <i>hnRNPI</i> KO, disrupt gut microbiota eubiosis, exacerbate colitis, and may potentially increase cancer risk.