Influenza A (flu) virus polymerase basic protein 2 (PB2) bound to VX787, an azaindole inhibitor

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抗流感病毒药物研发

PB2靶点抑制剂

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Influenza A (flu) virus polymerase basic protein 2 (PB2) bound to VX787, an azaindole inhibitor

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2023-12-27

Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors

抗流感病毒药物研发

双价抑制剂机制

Divalent inhibitors of the neuraminidase enzyme (NA) of the Influenza A virus were synthesized with vastly different spacers. The spacers varied from 14 to 56 atoms and were relatively rigid by way of

NIAID Data Ecosystem80

Identification of N- and C‑3-Modified Laudanosoline Derivatives as Novel Influenza PA N Endonuclease Inhibitors

抗流感病毒药物研发

PAN内切核酸酶抑制剂

Influenza PAN inhibitors are of particular importance in current efforts to develop a new generation of antiviral drugs due to the growing emergence of highly pathogenic influenza viruses and the resi

NIAID Data Ecosystem50

Synthesis, Optimization, and Structure–Activity Relationships of Imidazo[1,2‑ a ]pyrimidines as Inhibitors of Group 2 Influenza A Viruses

抗流感病毒药物研发

凝血因子抑制剂

The influenza A virus (IAV) is a highly contagious virus that causes pandemics and seasonal epidemics, which are major public health issues. Current anti-influenza therapeutics are limited partly due

NIAID Data Ecosystem30

Data_Sheet_1_Anti-influenza Virus Activity of Methylthio-Formycin Distinct From That of T-705.docx

抗流感病毒药物研发

抗病毒机制

Seasonal influenza virus epidemics result in severe illness, and occasionally influenza pandemics cause significant morbidity and mortality, although vaccines and anti-influenza virus drugs are availa

NIAID Data Ecosystem80

Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds

抗流感病毒药物研发

抗病毒活性

The synthesis of several 2,2-dialkyladamantyl-1-amines through the combination of a Ritter reaction with a Wagner–Meerwein rearrangement from noradamantane alcohols is reported. Several of the novel a

NIAID Data Ecosystem50

Influenza A (flu) virus polymerase basic protein 2 (PB2) bound to VX787, an azaindole inhibitor

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