Acute phase proteins in cats

ABSTRACT: Acute phase proteins (APP) are proteins synthesized and released largely by hepatocytes upon the occurrence of cell damage or invasion by microorganisms. This article reviews the use of APP in feline diseases, identifying their usefulness in the clinical setting, analyzing 55 published papers. Serum amyloid A, alpha-1 acid glycoprotein, and haptoglobin are the indicators pointed out by the authors as useful in monitoring the acute inflammatory response in cats. Although, APP measurement is still not routinely used in veterinary medicine, together with clinical signs and other blood parameters, was of clinical interest and applicability in diseases such as feline infectious peritonitis, pancreatitis, renal failure, retroviral and Calicivirus infections. Although, there are commercially available kits for dosing feline APP, assay standardization aiming technical simplicity, more species specificity and with less associated costs will allow routine use in feline practice, as it is done in the human field.摘要：急性期蛋白（Acute Phase Proteins，APP）是指在细胞损伤或微生物侵袭时，主要由肝细胞合成并释放的一类蛋白质。本文通过分析55篇已发表文献，综述了急性期蛋白在猫类疾病中的应用情况，明确了其在临床场景中的应用价值。作者指出，血清淀粉样蛋白A、α1-酸性糖蛋白以及结合珠蛋白可作为监测猫急性炎症反应的有效指标。尽管目前急性期蛋白检测尚未在兽医学中得到常规应用，但将其与临床症状及其他血液学指标相结合时，在猫传染性腹膜炎、胰腺炎、肾衰竭、逆转录病毒感染以及猫杯状病毒感染等疾病中具有临床应用价值与适用性。虽然目前已有商业化的猫类急性期蛋白定量检测试剂盒，但通过实现检测方法标准化，以达成操作简便、物种特异性更强且检测成本更低的目标，即可如同人类医学领域一般，在猫病临床实践中实现急性期蛋白检测的常规应用。