File S1 - Design of High-Specificity Nanocarriers by Exploiting Non-Equilibrium Effects in Cancer Cell Targeting

Contains supporting information on assumptions in our model regarding receptor availability and ligand interdependence, rate dependencies, definitions of and , and an analytic solution of the master equations and determination of the specificity for the case of steady state with constant endocytosis profile. Figure S1, Surface plot of specificity as a function of and , showing a ridge extending toward large values of (out of the page). For fixed and large , the specificity as a function of has a peak at . Here, and . Figure S2, Crossover value of overexpression factor as a function of affinity, , and number of ligands, (inset). for both plots, for the main plot and for the inset. In general, tends to qualitatively follow the behavior of the specificity for the same parameter values. (PDF)