XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon

XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon Descriptor: DI(HYDROXYETHYL)ETHER, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, OLEIC ACID, ... Authors: Stauch, B, Johansson, L.C, McCorvy, J.D, Patel, N, Han, G.W, Gati, C, Batyuk, A, Ishchenko, A, Brehm, W, White, T.A, Michaelian, N, Madsen, C, Zhu, L, Grant, T.D, Grandner, J.M, Olsen, R.H.J, Tribo, A.R, Weierstall, U, Roth, B.L, Katritch, V, Liu, W, Cherezov, V. Deposit date: 2018-09-05 Release date: 2019-04-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of ligand recognition at the human MT1melatonin receptor. Nature, 569, 2019

X射线自由电子激光（X-ray Free Electron Laser, XFEL）解析的人类褪黑素受体MT1与雷美替胺（ramelteon）复合物的晶体结构。组分描述：二(羟乙基)醚（DI(HYDROXYETHYL)ETHER）、N-{2-[(8S)-1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基]乙基}丙酰胺、油酸（OLEIC ACID）等。作者：Stauch B、Johansson L.C、McCorvy J.D、Patel N、Han G.W、Gati C、Batyuk A、Ishchenko A、Brehm W、White T.A、Michaelian N、Madsen C、Zhu L、Grant T.D、Grandner J.M、Olsen R.H.J、Tribo A.R、Weierstall U、Roth B.L、Katritch V、Liu W、Cherezov V。提交日期：2018年9月5日；发布日期：2019年4月24日；最后修改日期：2023年10月11日。实验方法：X射线衍射（2.8 Å）。引用文献：《人类MT1褪黑素受体配体识别的结构基础》，《自然》，569卷，2019年。