Changes in Treg gene expression upon deletion of Usp22 and Usp21

Usp22 and Usp21 are important for Foxp3 stability. We used RNA sequencing to determine the broad changes upon Usp22 and Usp21 deletionWe then performed gene expression profiling analysis using data obtained from RNA-seq and compared to each other Naïve natural Treg cells were isolated from murine spleens of Usp21-KO and Usp22 and Usp21-double KO mice. RNA isolated and sent for sequencing