Synthesis of Chiral and Modifiable Hexahydroxydiphenoyl Compounds
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https://figshare.com/articles/dataset/Synthesis_of_Chiral_and_Modifiable_Hexahydroxydiphenoyl_Compounds/2575933
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资源简介：
A reliable method for synthesizing each enantiomer of
the hexahydroxydiphenoyl
(HHDP) compounds has been developed. The synthesis involved atropselective
construction of the aryl–aryl bond of the HHDP compounds. This
construction relied on the CuCl2·n-BuNH2-mediated intramolecular coupling of bis(4-O-benzylgallate) on two simple chiral auxiliaries, both
of which were derived from l-(+)-tartaric acid. The coupling
reaction realized complete or near-perfect atropselectivity. The two
auxiliaries induced opposite axial chirality despite their identical
origin. The diastereoselectivities of these couplings were probably
controlled kinetically. Modifications of the free phenolic hydroxy
groups and the carbonyl groups in the resulting HHDP compounds demonstrated
the potential derivatization of a wide variety of HHDP analogues.
创建时间：
2011-12-02
