Maternal Diet During Early Gestation Influences Postnatal Taste Activity-Dependent Pruning By Microglia

Microglia aid in refining central gustatory circuits during normal development. This process is arrested by merely restricting their mother’s dietary sodium during a limited, early prenatal period when microglia progenitors migrate from the yolk-sac to the brain. Mothers fed low sodium (Na) or control diet during a defined window. Microglia were isolated using laser tissue microdissection.