Cardiac response to thromboxane-prostanoid receptor antagonism in a mouse model of muscular dystrophy

Expression analysis of left ventricle taken from wildtype or delta-sarcoglycan knockout mice, a model of muscular dystrophy. Mice were treated from weaning with vehicle or the thromboxane-prostanoid (TP) receptor antagonist ifetroban. Results provide insight into effects of TP receptor antagonism on cardiomyopathy of muscular dystrophy. Overall design: 2x2 design (WT/KO, vehicle/drug).