Directed, Palladium(II)-Catalyzed Intermolecular Aminohydroxylation of Alkenes Using a Mild Oxidation System
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https://figshare.com/articles/dataset/Directed_Palladium_II_-Catalyzed_Intermolecular_Aminohydroxylation_of_Alkenes_Using_a_Mild_Oxidation_System/6473132
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资源简介：
A palladium(II)-catalyzed
β,γ-aminohydroxylation reaction
of nonconjugated alkenyl carbonyl compounds has been developed. This
reaction utilizes a cleavable bidentate directing group to achieve
regioselective aminopalladation. The resulting chelation-stabilized
alkylpalladium(II) intermediate is then hydroxylated using oxygen/2,6-dimethylbenzoquinone
in HFIP as the mild oxidation system. Under the optimized conditions,
various nucleophiles and alkene substrates are capable of delivering
good yields and high diastereoselectivities of the aminohydroxylated
products.
创建时间：
2018-06-12
