AKR dimers reduce AFBDHO to AFBDOH

Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) are dimeric, cytosolic, NADPH-dependent enzymes able to catalyse the reduction of aflatoxin B1 dialdehyde (AFBDHO) to aflatoxin B1-6,8-dialcohol (AFBDOH) (Ellis et al. 2003, Bodreddigari et al. 2008, Ireland et al. 1998, Guengerich et al. 2001). AKRs can turnover a vast range of substrates, including drugs, carcinogens, and reactive aldehydes. They play central roles in the metabolism of these agents, leading to either their bioactivation or detoxication (Jin & Penning 2007). The dialcohol is excreted in urine by conjugation with glucuronide (not shown here).

黄曲霉毒素B1醛还原酶（AKR7A2、AKR7A3和AKR7L）是一种二聚体、细胞质内、依赖于NADPH的酶，能够催化黄曲霉毒素B1二醛（AFBDHO）还原为黄曲霉毒素B1-6,8-二醇（AFBDOH）（参见Ellis等人，2003年；Bodreddigari等人，2008年；Ireland等人，1998年；Guengerich等人，2001年）。AKR酶系能够代谢广泛的底物，包括药物、致癌物和活性醛类。它们在代谢这些物质的过程中扮演核心角色，导致其生物转化或解毒（Jin & Penning，2007年）。二醇通过与葡萄糖醛酸结合（此处未展示）排出尿液。