Metal-Free Oxidative Thioesterification of Methyl Ketones with Thiols/Disulfides for the Synthesis of α‑Ketothioesters
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资源简介：
A direct Csp3–H bond oxidative thioesterification of methyl ketones with aromatic thiols/disulfides promoted by TBAI/K2S2O8 has been developed. The reaction provides successfully a simple and efficient method for the synthesis of functionalized α-ketothioesters of aromatic thiols. This practical methodology exhibits readily available starting materials, large-scale applicability, synthetic application, and broad functional group tolerance. A possible mechanism for the transformation is proposed.
创建时间：
2018-11-29
