IntroductionSmall colony variant (SCV) is a bacterial phenotype closely related to persistent and recurrent infections. SCVs are mutations that occur within bacterial populations, resulting in a chang

NIAID Data Ecosystem00

Table 1_The dltC gene contributes to polyhexamethylene biguanide resistance in Staphylococcus aureus.docx

细菌耐药性机制

聚六亚甲基双胍耐药性

As the efficacy of conventional antibiotics continues to decline due to antibiotic resistance, there is an urgent need for alternative antimicrobial strategies. Polyhexamethylene biguanide (PHMB), a c

NIAID Data Ecosystem00

Exogenous pyruvate promotes gentamicin uptake to kill antibiotic-resistant Vibrio alginolyticus

细菌耐药性机制

细菌代谢干预治疗

Exogenous pyruvate promotes gentamicin uptake to kill antibiotic-resistant Vibrio alginolyticus

integrated proteome resources30

Development and application of CRISPR/Cas9-assisted genome-editing tools for comprehensive investigation the role of efflux pumps in Mycobacterium abscessus

细菌耐药性机制

外排泵毒力功能

Using CRISPR/Cas9-assisted genome-editing tools, we constructed 68 efflux pump mutants of M. abscessus and investigated their roles in drug resistance and virulence. We found that different efflux pum

NIAID Data Ecosystem00

Aminoglycoside Phosphotransferase (2'')-Ia S376N mutant in complex with GMPPNP and Magnesium

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