Crystal Structure of Arabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1(AtPFA-DSP1 ) Cys150Ser in complex with 5-diphosphoinositol 1,3,4,6-tetrakisphosphate (5PP-InsP4) and phosphate in conformation B (Pi(B))

Crystal Structure of Arabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1(AtPFA-DSP1 ) Cys150Ser in complex with 5-diphosphoinositol 1,3,4,6-tetrakisphosphate (5PP-InsP4) and phosphate in conformation B (Pi(B)) Descriptor: (1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, PHOSPHATE ION, Tyrosine-protein phosphatase DSP1 Authors: Wang, H, Shears, S.B. Deposit date: 2021-05-01 Release date: 2022-03-02 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A structural expose of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop. Nat Commun, 13, 2022

拟南芥（Arabidopsis thaliana）与真菌来源的非典型双特异性磷酸酶1（AtPFA-DSP1）的Cys150Ser突变体，与5-二磷酸肌醇1,3,4,6-四磷酸（5-diphosphoinositol 1,3,4,6-tetrakisphosphate，简称5PP-InsP4）及构象B下的磷酸根（Pi(B)）形成复合物的晶体结构。描述符：(1r,2R,3S,4r,5R,6S)-4-羟基-2,3,5,6-四(膦酰氧基)环己基三氢二磷酸、磷酸根离子、酪氨酸蛋白磷酸酶DSP1。作者：Wang, H、Shears, S.B.。沉积日期：2021年5月1日，发布日期：2022年3月2日，最后修改日期：2024年5月22日。实验方法：X射线衍射（分辨率1.9埃）。引用：《蛋白质酪氨酸磷酸酶WPD环内非经典分子反应性的结构解析》，《自然-通讯》（Nat Commun），第13卷，2022年。