FAIRsharing record for: FerrDb V2

This FAIRsharing record describes: FerrDb V2 contains 1001 ferroptosis regulators and 143 ferroptosis-disease associations manually curated from 3288 articles. Specifically, there are 621 gene regulators, of which 264 are drivers, 238 are suppressors, 9 are markers, and 110 are unclassified genes; and there are 380 substance regulators, with 201 inducers and 179 inhibitors. Compared to FerrDb V1, curated articles increase by > 300%, ferroptosis regulators increase by 175%, and ferroptosis-disease associations increase by 50.5%. Circular RNA and pseudogene are novel regulators in FerrDb V2, and the percentage of non-coding RNA increases from 7.3% to 13.6%. External gene-related data were integrated, enabling thought-provoking and gene-oriented analysis in FerrDb V2.

本FAIRsharing记录描述如下：FerrDb V2共收录1001个铁死亡（ferroptosis）调控因子与143个铁死亡-疾病关联，所有数据均从3288篇经人工甄选的文献中提取。具体而言，其中包含621个基因类调控因子，细分为264个驱动因子、238个抑制因子、9个标志物以及110个未分类基因；另有380种物质类调控因子，包括201种诱导剂与179种抑制剂。相较于FerrDb V1版本，经人工甄选的文献数量增幅超300%，铁死亡调控因子总量增长175%，铁死亡-疾病关联数量提升50.5%。环状RNA（Circular RNA）与假基因（pseudogene）为FerrDb V2新增的调控因子类别，且非编码RNA（non-coding RNA）的占比从7.3%升至13.6%。本数据集整合了外部基因相关数据，可支持开展富有启发性的基因导向性分析。