Human Vaginal Microbiota Metagenome

This study includes only 115 participants (women of reproductive age) and approximately 499,000 reads (passed our quality control). The aim of our present study was to explore the real world of the vaginal microbiota after bacterial vaginosis treated with metronidazole and probiotic Lactobacillus. We investigated the overall structure and composition of vaginal microbiota with 454 pyrosequencing The human vaginal microbiota from 30 cases of bacterial vaginosis after treated with metronidazole (BV-M, 500mg, 7 days) intravaginally, 25 cases of bacterial vaginosis after treated with probiotic Lactobacillus (BV-L, more than 10E 09 CFU, 10 days) intravaginally, 30 cases of bacterial vaginosis without treatment (BV) and 30 cases of healthy control (CN). For the two actively treatment groups, the vaginal swabs were taken 5 days after the last administration of the medication. Clinical Trial Registration: ChiCTR-TRC-11001484 (www.chictr.org).