WGS_LOS_5K_Chr20.vcf.gz

Louisiana Osteoporosis Study (LOS) is an ongoing research study and has recruited >17,000 individuals since 2011. The aim of it is to investigate the genetic risk factors of osteoporosis and other complex diseases. We selected 4,986 unrelated subjects including 2,110 African Americans and 2,876 Caucasians randomly (stratified by sex and race groups) from the whole LOS cohort. WGS of the blood samples had an average sequencing depth of 22× and were aligned to the human reference genome (version GRCh38/hg38). The chromosome 20 of the LOS data has totally 3,098,112 Single-nucleotide variants (SNVs). After quality control including sample and single-nucleotide polymorphism (SNP) filtering (e.g., missing ratio>0%, Hardy-Weinberg equilibrium (HWE) p-value