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Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T-cells

NIAID Data Ecosystem2026-03-14 收录

T细胞耗竭

转录因子免疫调节

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE212806 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2023-01-04

肿瘤免疫学

T细胞耗竭

We aimed to investigate the association between HPK1 expression and exhausted status of tumor. Overall design: Bulk RNA-seq was performed on fresh-frozen tissue samples of renal cell carcinoma.

NIAID Data Ecosystem60

RNA-Seq analysis of P14 CD8+T cells in B16-GP tumors

肿瘤浸润T细胞

T细胞耗竭

CD8+ T cells play an important role in fighting against tumors. However, CD8+ T cells often become functionally impaired or “exhausted” in the tumor microenvironment. T cell exhaustion is a major hurd

NIAID Data Ecosystem60

Correlations of clinical parameters and T cell markers.

病毒感染免疫反应

T细胞耗竭

Spearman correlations of HCV-RNA and ALT with expression of activation and exhaustion markers and median expression of these markers in patients with F0–F2 versus F3–F4 fibrosis in all HCV-monoinfecte

Figshare2015-12-02 更新50

Disturbed mitochondrial dynamics in CD8+ TIL reinforce epigenetic programming linked with T cell exhaustion

免疫代谢

T细胞耗竭

The metabolic challenges present in tumors attenuate the metabolic fitness and anti-tumor activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether persistent metabolic

NIAID Data Ecosystem60

scRNA-seq of antigen-specific CD8+ T cells from tumor draining LN, TIL and PBMC of melanoma bearing mice

肿瘤免疫

T细胞耗竭

CD8+ T cell-mediated immune response plays a pivotal role in controlling tumor growth.However, within the tumor microenvironment (TME), prolonged antigen exposure, as well as immunosuppressive factors

NIAID Data Ecosystem60

Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T-cells

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