Data from: Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis

Mammalian sex is determined by opposing networks of ovarian and testicular genes that are well characterized. However, its epigenetic regulation is still largely unknown, thus limiting our understanding of a fundamental process for species propagation. Here we explore the 3D chromatin landscape of sex determination in vivo, using METALoci, a novel genome spatial auto-correlation analysis.

Extended Data File 1: Coordinates for HH metaloci in each sample.

The EDFile1_H3K27ac_HH_metaloci_per_gene.zip file contains four files named:

XX10.5_H3K27ac_HH_metaloci_per_gene.bed

XX13.5_H3K27ac_HH_metaloci_per_gene.bed

XY10.5_H3K27ac_HH_metaloci_per_gene.bed

XY13.5_H3K27ac_HH_metaloci_per_gene.bed

Each BED file contains the following columns tab separated:

chr                  Chromosome

start                Start coordinates

end                  End coordinates

MetaLociBinNumber     Number of the bin in the METALoci layout

GeneSymbol            Gene symbol

Extended Data File 2: Coordinates bins in METALoci with ATAC-seq accessible peak targeted by TF.

The EDFile2_TF_ATAC_ML_Sites.zip file contains four files named:

XX10.5_TF_ATAC_ML_Sites.tsv

XX13.5_TF_ATAC_ML_Sites.tsv

XY10.5_TF_ATAC_ML_Sites.tsv

XY13.5_TF_ATAC_ML_Sites.tsv

Each TSV file contains the following columns tab separated:

chr            Motif site chromosome 

start          Motif site start coordinates 

end            Motif site end coordinates

bin            Hi-C bin number

pchr           ATAC site chromosome

pstart         ATAC site start coordinates

pend           ATAC site end coordinates

gene           Gene symbol