Serum and hematological parameters in GRMD dogs.

Mean values for altered serum and hematological parameters from GRMD dogs during the nine weeks of the study. The times represent the bortezomib treatment period in the treated dogs (K1 and B7). The parameter with the greatest change was serum CK concentration, with a high magnitude range of 40 to 70 times the reference value from Kaneko et al. (1997). CK: creatine kinase