Effects of combinations of peramivir and favipiravir on oseltamivir-resistant K/2785 virus infection in mice.

aSee Table 2, footnote a. bSee Table 2, footnote b. cIncrease in lifespan of the infected mice was determined using the MDD results (the MDD of a combination therapy group compared with that of a longer living group between two respective monotherapy groups). dSynergism was evaluated by MacSynergy II software. Fisher’s exact test was applied to determine the statistical significance of differences in the survival rates (*, P<0.05, **, P<0.01, and ***, P<0.001 compared with the placebo mice group).