Rhodium-Catalyzed Asymmetric One-Pot Transesterification and [2 + 2 + 2] Cycloaddition Leading to Enantioenriched 3,3-Disubstituted Phthalides

We have developed a cationic rhodium(I)/Solphos complex-catalyzed asymmetric one-pot transesterification and [2 + 2 + 2] cycloaddition of
1,6-diyne esters with tertiary propargylic alcohols leading to enantioenriched tricyclic 3,3-disubstituted phthalides. The present method represents
a versatile new route to the synthesis of enantioenriched tricyclic 3,3-disubstituted phthalides in view of the easy access to both coupling
partners.