Pioneer factor ETV2 safeguards endothelial cell specification. Pioneer factor ETV2 safeguards endothelial cell specification

Mechanisms of cell fate specification are central to developmental biology and regenerative medicine. ETV2 is a master regulator for the endothelial cell lineage specification. Here, we study mechanisms by which ETV2 overexpression in human iPSC-derived mesodermal progenitors efficiently specifies ECs. Overall design: Chromatin accessibility, gene expression profiling, and TF chromatin occupancy was assessed using high-throughput sequencing.