Specialized Pro-resolving Mediators Regulate Treg Differentiation. Specialized Pro-resolving Mediators Regulate Treg Differentiation
收藏NIAID Data Ecosystem2026-03-11 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA590755
下载链接
链接失效反馈官方服务：
资源简介：
We aim to demonstrate a central role for omega-3 derived autacoids, termed specialized pro-resolving mediators (SPM), in the differentiation and maturation of Tregs. Overall design: Naïve CD4+ T lymphocytes were isolated by immunomagnetic negative selection from the spleens of 4 WT and 4 Alox15-/- mices (KO). Tregs were differentiated from naïve CD4+ T lymphocytes for 2 days in the presence of IL-2, TGF-β and CD3/CD28 activation beads. Using RNA sequencing we assessed the differential gene expression between KO and WT mices.
创建时间：
2019-11-20
