Exp. 7f - Mass Cytometry of FVB/N WEA tumors with and without WEA p53ko-conditioned adipocytes
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http://flowrepository.org/id/FR-FCM-Z6W9
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资源简介：
The aim of this experiment was to evaluate the effect of p53-ko conditioned adipocytes on the immune landscape of WEA tumors. The hypothesis was that tumors with p53-ko conditioned adipocytes, even if the p53 status of the cancer cells is wt, will be more immunosuppressed.
Conclusion:
p53-ko conditioned adipocytes increase the abundance of myeloid-derived suppressor cells within the tumor microenvironment, accompanied by upregulation of the immune checkpoint marker PD-L1, both are known to favor tumor progression.
Notes:
8-week-old FVB/N female mice were used and tumors were harvested 20 days after injection. Each tumor type had four biological repeats.
创建时间：
2023-08-01
