Hydrogen-Bond-Directed Formal [5 + 1] Annulations of Oxindoles with Ester-Linked Bisenones: Facile Access to Chiral Spirooxindole δ‑Lactones
收藏NIAID Data Ecosystem2026-03-08 收录
下载链接：
https://figshare.com/articles/dataset/Hydrogen_Bond_Directed_Formal_5_1_Annulations_of_Oxindoles_with_Ester_Linked_Bisenones_Facile_Access_to_Chiral_Spirooxindole_Lactones/2313205
下载链接
链接失效反馈官方服务：
资源简介：
A novel
bifunctional thiourea catalyzed formal [5 + 1] cycloaddition
of oxindoles and ester-linked bisenones was successfully developed.
This strategy involves two sequential Michael additions, leading to
spirooxindole δ-lactones with three contiguous stereocenters
including an all-carbon quaternary center with high diastereo- and
enantioselectivites. In addition, a remarkable N-substituent effect
was observed on the reactivity and selectivity.
创建时间：
2016-02-17
