Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus
收藏干细胞与再生医学数据中心2021-09-08 更新2024-03-06 收录
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To delete EED from NSPCs and their progeny, we created
Eedf/f;hGFAP-Cre+ (hereafter referred to as cKO) by crossing
Eedf/f with hGFAP-Cre transgene mice.The morphology of hippocampal DG region was analyzed by frozen section staining, and the expression of various cells in hippocampal region was analyzed by immunostaining.The downstream target genes were identified by RNA-seq and functional cluster analysis.ChIP-qPCR was used to prove that EED can directly regulate downstream target genes.The effective target gene was proved by functional recovery experiment.
提供机构：
中国科学院动物研究所
创建时间：
2021-09-08
