Data underlying the publication: "Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls"

This study extends a previous 1D agent-based model for Notch signaling in arteries to a 2D formulation. This allows investigation of the effects of cell connectivity on the dynamics of arterial Notch signaling and VSMC phenotypes. Notch signaling for VSMCs with 2-6 neighbouring cells was analyzed. Computational results of the 1D and 2D formulations were also compared.

本研究将既往针对动脉组织中Notch信号通路的一维基于智能体模型拓展至二维模型形式。该拓展使得本研究得以探究细胞连接性对动脉Notch信号通路动力学及血管平滑肌细胞（vascular smooth muscle cells, VSMC）表型的影响。本研究针对拥有2至6个相邻细胞的血管平滑肌细胞的Notch信号通路展开了分析，并对一维与二维模型的计算结果进行了对比。