Precise NMR Method for Titering Organometal Reagents

The
concentration of organometal reagents can be conveniently determined
by obtaining the NMR spectra of the neat reagent solution, and, in
a second NMR tube, of a neat reference solvent. The PULCON relationship,
implemented in all major NMR software, is then used to calculate the
concentration of the reagent based on the absolute integrals in the
spectra, the known concentration of the reference, and the number
of protons under the integrals.