RNA sequencing of control and dnm2-knockout mouse sciatic nerves

In this study, we analyzed the transcriptome profiles of mouse sciatic nerves after developmental (P1 and P5) or inducible (4 weeks post Tamoxifen) deletion of Dnm2 conditionally in Schwann cells (using a P0Cre-driven or a P0CreERT2-driven recombination of floxed alleles, respectively) as compared to controls (floxed Dnm2 homozygous, Cre-negative). Overall design: mRNA profiles from controls and mutants were collected in triplicate from developmental sciatic nerves at P1 and P5, as well as from inducible mice at 4 weeks post tamoxifen