Crystal structure of human cellular retinol binding protein 1 in complex with N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-(2-thienylmethyl)methanamine

Crystal structure of human cellular retinol binding protein 1 in complex with N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-(2-thienylmethyl)methanamine Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-methyl-1-{3-[1-(4-methylphenyl)cyclopentyl]-1,2,4-oxadiazol-5-yl}-N-[(thiophen-2-yl)methyl]methanamine, Retinol-binding protein 1 Authors: Plau, J, Golczak, M. Deposit date: 2023-03-03 Release date: 2023-10-04 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. Acs Chem.Biol., 18, 2023人源细胞视黄醇结合蛋白1（cellular retinol binding protein 1, CRBP1）与N-甲基-1-{3-[1-(4-甲基苯基)环戊基]-1,2,4-噁二唑-5-基}-N-(2-噻吩甲基)甲胺复合物的晶体结构 描述项：2-[双(2-羟乙基)氨基]-2-羟甲基-丙烷-1,3-二醇、N-甲基-1-{3-[1-(4-甲基苯基)环戊基]-1,2,4-噁二唑-5-基}-N-[(噻吩-2-基)甲基]甲胺、视黄醇结合蛋白1 作者：Plau J, Golczak M. 存档日期：2023-03-03 发布日期：2023-10-04 最后修改日期：2023-11-01 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.13埃） 引用文献：《CRBP1非视黄醇类抑制剂的发现：配体结合机制的结构与动态洞察》，《ACS化学·生物学》（Acs Chem.Biol.），第18卷，2023年