Impact of the treatments on neurological score, infarct size and edema volume.

Treatments were: empty microparticles (n = 8), free GSNO at 7.5 mg/kg (n = 8) and in situ implants loaded at 30.1 ± 1.5 mg/kg (n = 8) or microparticles at 31.4 ± 0.9 mg/kg (n = 6) of GSNO, injected in male Wistar rats 2 h after thromboembolic stroke induction. Neurological score (panel A, maximal score 160) was measured 24 and 48 h after stroke induction, infarct size (panel B) and edema volume (panel C) 48 h after. *: p vs. empty microparticles; #: p vs. free GSNO at 7.5 mg/kg; ο: p vs. in situ implants (Kruskal-Wallis; post-hoc Mann-Whitney test).