EPIDEMIOLOGICAL CHARACTERISTICS OF METABOLIC RISK FACTORS FOR GASTRODUODENAL ULCERS IN THE POPULATION OF LONG-LIVERS

Even in developed countries, peptic ulcer disease (PUD) occurs in about 1.8% of the population. The incidence equally affects both men and women. According to clinical studies, 20–50% of patients with gastric and duodenal ulcers (GDU) demonstrate a family predisposition (Rothenbacher D., Lw M., Hardt P.D. et al., 2005). Research data indicate that peptic ulcer disease combined with other acid-related disorders is diagnosed in 40–50% of cases, often leading to severe complications and disability (Podoluzhny V.I., 2019), or requires revision of cancer prevention strategies. This is due to the fact that in the presence of GDU and pre-ulcer conditions, the cascade of carcinogenesis accelerates within the population. In the scientific literature, an epidemiological axiom has emerged stating that in cases of pre-ulcer conditions associated with H. pylori, gastric cancer may develop. Recommendations for monitoring precancerous changes of the stomach suggest increasing the frequency of endoscopic examinations in accordance with the carcinogenesis risk (endoscopic cancer-prevention scheme), i.e., the practice of preventive protection is applied.