Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathw
Human brain tissues were examined by electron microscope and secretory granule-like vesicles (large dense-core vesicles) of astrocytes were shown. SG, secretory granule-like vesicles; ax, axon; fm, fi
GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp
Projection through merged optical section series of a filled astrocyte (green) in the molecular layer of the dentate gyrus, stained for EphA4 (red), showing the relationship between astrocyte proces
