miRNA profiling during radiotherapy for breast cancer

The aim of the present investigation was to test if microRNA levels in peripheral blood lymphocytes of breast cancer patients treated by external beam radiotherapy were predictive of the absorbed dose. Leukocytes were isolated from blood samples collected prior to exposure (control), on the day after one fraction (2 Gy), five fractions (10 Gy), ten fractions (20 Gy), and finally at one month after 23–25 fractions (total dose of 46–50 Gy).